Abstarct: This study aimed to evaluate the feasibility of gold recovery from sulfide ore of the Hired gold mine via alkaline oxidation followed by cyanidation. In the initial PHase, approximately 70 kg of sulfide ore samples were collected from the mine’s sulfide dump and prepared through crushing and homogenization. Comprehensive characterization was conducted using X-ray diffraction (XRD), X-ray fluorescence (XRF), sieve analysis, and microscopic examination of thin and polished sections. Results indicated that the ore contained approximately 52% silica, with an average gold grade of 1240 ppb. The iron and sulfur contents were approximately 4% and 2.5%, respectively. In the subsequent PHase, key parameters influencing the alkaline oxidation and cyanidation processes—including pulp PH, pulp temperature during oxidation, oxidation time, leaching time, and cyanide concentration—were identified. Experimental design was conducted utilizing response surface methodology (RSM) and central composite design (CCD) to systematically evaluate the effect of each parameter. The maximum gold recovery of 62.62% was achieved under operational conditions of PH 12, oxidation temperature of 60°C, oxidation time of 30 hours, leaching time of 30 hours, and cyanide concentration of 1400 g/t. Statistical analysis via RSM revealed that pulp PH and oxidation temperature had the most significant impact on gold dissolution efficiency, whereas sodium cyanide concentration exhibited the least effect.