Abstarct: The sedimentation process in the mining industry, particularly in concentrate plants, plays a fundamental role in water recovery and reducing chemical consumption. Controlling and optimizing the dosage of flocculants in thickeners not only reduces operational costs but also minimizes environmental impacts and enhances the efficiency of the treatment process. Therefore, this study was conducted to optimize flocculant consumption in thickeners TH01 and TH02 at the Sangan Khorasan Steel Concentrate Plant. Accordingly, initially the effects of operating parameters including flocculant type and concentration, dosage, pH, and solids percentage on thickener performance were evaluated with a focus on overflow water clarity and sedimentation rate. Results showed that flocculant A28 produced higher clarity at lower concentrations, while flocculant A26 achieved the highest sedimentation rate under optimal conditions. Subsequently, using Response Surface Methodology (RSM) and Central Composite Design (CCD), mathematical models were developed to predict turbidity and sedimentation rate, with determination coefficients (R²) of 0.922 and 0.713, respectively. Optimization results indicated that under optimal conditions including 0.3 g/L concentration, 30 g/ton dosage, and use of flocculant A26 turbidity reached 44.8 NTU and sedimentation rate reached 5.6 m/h. The findings also demonstrated that applying optimal operating conditions reduced flocculant consumption by approximately 30%, improved the quality of recovered water, and increased sedimentation process efficiency.