Abstarct: The purpose of this research was to experimentally investigate copper leaching from the soil sample of Koh Khairi mine with tank leaching method. For achieving this the aim, the research program was divided into three working phases. In first, the received sample was prepared and the representative sample was provided. Then, the chemical and mineralogy analysis of the representative sample was carried out by the dimensional analysis of particles, XRF, XRD, atomic absorption and the study of thin and polished sections. The results indicated that the content of total copper is equal to 0.54. The sieving analysis of the received soil sample showed that 86.78% of the particles are less than 2 mm (10 mesh sieve) and d80 is almost equal to 12 mesh (1680 µm) sieve. The mineralogical study of the sections showed that more than 80% of copper minerals are in secondary form (mostly carbonate/sometimes silicate) and less than 20% are in primary form (sulfide). Meanwhile, about 90% of non-mextallic copper minerals are green (such as malachite) and about 10% of copper minerals tend to be blue (chrysocolla). In second stage, the behavior of parameters was examined with the one factor at a time method. The findings demonstrated that the amount of extracted copper increased with increasing the acid concentration, leaching time and the solid percent. The sieve analysis indicated that 0-2 mm size was a better choice for the leaching tank than other fractions including 0-500 µm, 0-1 mm and the main received sample (0-4 mm). However, the acid test with rolling bottle confirmed that the amount of acid used for the studied sample was very high, and this was due to the presence of silicate and clay compounds in the sample. Also the stirring speed of pulp had a little effect on the extraction process of copper compared to other factors and confirmed that the mixing rate of pulp should be at a level that suspends the particles of the sample and prevents them from settling. In third stage, modeling, optimizing and evaluating the interaction effects of parameters was conducted using the statistical design of experiments baxsed on response surface methodology-central composite design. The results showed that the effect of leaching time, solid percent, acid concentration and interaction between factors respectively had the greatest effect on the efficiency of copper dissolution and the recovery of copper leaching was strongly dependent on the interaction between the factors. In addition, optimization process was performed with the desirability function approach and the optimum conditions including the acid concentration about 90 Kg/t, solid percentage of 35, pulp mixing rate of 150 rpm, leaching time of 2.5 h, size range of 0-2 mm were obtained with the desirability of 0.8. Under these conditions, the leaching recovery of copper was above 72%. Six additional tests for optimization and confirmation were conducted within the range of optimum conditions on 0-2 mm size and it was confirmed that the pregnant leach solution (PLS) with a copper content of about 2.2 g/l and the extraction efficiency of more than 70% could be acquired under the suggested optimum conditions. Eventually, the kinetics of the process was investigated, which showed that the fluid penetration model through the production laxyer with an activation energy of 14.15 kJ/mol controls the reaction rate.