Abstarct: In this study, three types of inorganic composites baxsed on mextal-organic frxameworks (MOFs) and functional polysiloxanes were synthesized. The optical, physical, and chemical properties of the prepared composites were investigated using UV-Vis-DRS, FE-SEM, EDS, FT-IR, XRD, and XPS analyses. These materials can be utilized in two significant areas: drug delivery and photo-catalytic processes. The first composite from poly(chloropropyl)silsesquioxane with ZIF-8 allows the effective loading of tetracycline or acyclovir onto the surface of the structure, and the controlled release of these drugs in response to pH were evaluated. MTT assay on fibroblast cell line indicated that the composite has no cytotoxicity on this cell line and after loading of tetracycline or acyclovir, the cytotoxicity even decreased and the growth of cells became higher than positive control. Additionally, the antibacterial activity against Staphylococcus aureus and Pseudomonas aeruginosa was also evaluated and confirmed the positive effect of this composite before and after both drugs loading against growth of these bacteria and the most effective sample was tetracycline loaded composite against growth of both bacteria. In continue the composites of poly(amino-propyl)silsesquioxane with MIL-100(Fe) and poly(chloro-propyl)silsesquioxane with UIO-66-NH2 were prepared and their activity in photocatalytic processes for the degradation of tetracycline and chlorotetracycline demonstrated that both composites are effectively capable of degrading these pharmaceuticals in wastewater. The use of various scavengers indicated that O₂°⁻ (superoxide) is the main reactive species generated by these composites during the photo-catalytic degradation of tetracycline and chlorotetracycline. Furthermore, the results showed both photo-catalytic composites can be recycled up to three times.